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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
RET
All Species:
10.3
Human Site:
Y981
Identified Species:
20.61
UniProt:
P07949
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P07949
NP_065681.1
1114
124319
Y981
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
Chimpanzee
Pan troglodytes
XP_001171246
813
90715
G688
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
Rhesus Macaque
Macaca mulatta
XP_001090823
731
81824
G606
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
Dog
Lupus familis
XP_543915
1108
124018
Y975
D
N
C
S
E
E
M
Y
G
L
M
L
Q
C
W
Cat
Felis silvestris
Mouse
Mus musculus
P35546
1115
123855
Y982
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
Rat
Rattus norvegicus
Q04589
822
91806
G697
L
W
E
I
F
T
L
G
G
S
P
N
P
G
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507715
665
75620
K540
N
L
M
L
R
C
W
K
Q
E
P
D
K
R
P
Chicken
Gallus gallus
P18461
823
92281
I698
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Frog
Xenopus laevis
Q03364
813
91322
T688
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
Zebra Danio
Brachydanio rerio
Q8JG38
817
91370
I692
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q09147
1052
117795
Y927
S
Q
S
D
V
W
S
Y
G
V
L
L
W
E
I
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Q26614
972
110463
L847
D
V
W
S
F
G
I
L
L
W
E
I
M
T
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
28.4
27.9
86.4
N.A.
83.4
28.9
N.A.
43
27.5
28.1
27.7
N.A.
23.6
N.A.
N.A.
24
Protein Similarity:
100
42.2
41.5
92
N.A.
90.2
43
N.A.
50.5
43.5
42.3
42
N.A.
37.7
N.A.
N.A.
41.2
P-Site Identity:
100
0
0
93.3
N.A.
100
0
N.A.
0
0
6.6
0
N.A.
13.3
N.A.
N.A.
13.3
P-Site Similarity:
100
6.6
6.6
93.3
N.A.
100
6.6
N.A.
20
6.6
6.6
6.6
N.A.
26.6
N.A.
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
25
0
0
9
0
0
0
0
0
0
0
25
0
% C
% Asp:
34
0
0
9
0
0
0
0
0
0
0
9
0
0
0
% D
% Glu:
0
0
25
0
34
25
17
0
0
9
9
0
0
9
0
% E
% Phe:
17
0
0
0
34
0
9
0
17
0
0
0
0
0
0
% F
% Gly:
0
17
0
0
0
9
0
25
42
9
9
17
17
25
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
25
0
9
9
17
0
0
0
9
0
0
9
% I
% Lys:
0
0
0
0
0
0
0
9
0
0
0
0
9
0
0
% K
% Leu:
25
17
0
25
0
0
25
9
17
25
25
34
0
0
9
% L
% Met:
0
0
17
0
17
0
25
0
0
0
25
0
9
0
0
% M
% Asn:
9
25
0
0
0
0
0
0
0
0
0
9
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
34
0
34
0
34
% P
% Gln:
0
9
0
0
0
0
0
0
9
0
0
0
25
0
0
% Q
% Arg:
0
0
0
0
9
0
0
0
17
0
0
0
0
9
0
% R
% Ser:
9
0
9
34
0
0
9
0
0
25
0
9
0
17
0
% S
% Thr:
0
0
0
0
0
25
0
9
0
17
0
0
0
9
0
% T
% Val:
9
9
17
0
9
0
0
0
0
9
0
0
0
0
25
% V
% Trp:
0
25
9
9
0
25
9
0
0
9
0
0
9
0
25
% W
% Tyr:
0
0
0
0
0
0
0
34
0
0
0
17
0
9
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _